OE Gamechanger is a comprehensive joint health formula that supports healthy joints and flexibility. It is one of only two products that contain a novel, patented joint support matrix containing Phycocyanin. Phycocyanin is a natural antioxidant that has powerful free radical scavenging properties and that supports the body’s normal defense again the harmful effects of free radicals that cause cellular damage and inflammation. Phycocyanin is natural cox 2 inhibitor, bute and equioxx are pharmaceutical cox 2 inhibitors. This is a great product for helping with a horse’s natural pain management and inflammation response that will not test.